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Which of the following effects of tobacco use negatively impacts wound healing?

  1. Increased blood circulation

  2. Reduced delivery of oxygen to the wound bed

  3. Enhanced immune response

  4. Decreased infection rates

The correct answer is: Reduced delivery of oxygen to the wound bed

Tobacco use significantly hinders wound healing primarily by reducing the delivery of oxygen to the wound bed. Nicotine and other harmful substances in tobacco constrict blood vessels, which diminishes overall blood flow. Adequate blood circulation is vital for wound healing because it facilitates the delivery of oxygen and essential nutrients necessary for tissue repair and regeneration. Oxygen is critical for cellular metabolism and the formation of new tissue, so when its delivery is compromised, healing is slowed, and the risk of complications increases. The other choices present effects that would not align with the adverse impact of tobacco on wound healing. For instance, increased blood circulation, enhanced immune response, and decreased infection rates all suggest improvements in healing conditions, which are opposites of what occurs due to tobacco use. Thus, the option highlighting reduced oxygen delivery clearly indicates a detrimental effect on the wound healing process.